Following a modified Atkins food plan excessive in fats and low in carbohydrates plus taking remedy could scale back seizures in folks with tough-to-treat epilepsy, in line with a research printed within the January 4, 2023, on-line subject of Neurology®, the medical journal of the American Academy of Neurology.
“For folks with drug-resistant epilepsy, or those that have been unable to seek out efficient remedy to scale back seizures, it is encouraging to see that there are way of life modifications that may be mixed with commonplace drug remedy to scale back the variety of seizures,” mentioned research writer Manjari Tripathi, MD, DM, of All India Institute of Medical Sciences in New Delhi. “Our research discovered that this mix could scale back the possibility of seizures by greater than half.”
The modified Atkins food plan is a mix of the Atkins food plan and a ketogenic food plan that features meals objects resembling soy merchandise, heavy cream, butter and oils, leafy inexperienced greens, and animal protein together with eggs, hen, fish, and bacon. Whereas the ketogenic food plan has been proven to be efficient in lowering seizures, its stringent necessities and restrictions could make it tough to comply with.
The research concerned 160 adults and adolescents who had epilepsy for greater than 10 years on common and had a minimum of 27 seizures per 30 days regardless of making an attempt a median of 4 antiseizure drugs on the most tolerated dose. They have been randomly assigned to obtain both commonplace drug remedy alone or medicine plus the modified Atkins food plan over six months.
Members logged their seizures and meals. They got meals lists, pattern menus and recipes. Carbohydrate consumption was restricted to twenty grams per day. Federal dietary tips advocate between 225 and 325 grams of carbs per day.
After six months, researchers discovered that 26% of people that had each drug remedy and adopted the modified Atkins food plan had greater than a 50% discount in seizures in comparison with solely 3% of the individuals who had drug remedy alone. 4 folks within the food plan group have been freed from seizures by the tip of the research, whereas nobody within the medication-only group was seizure free.
The research additionally checked out high quality of life, habits and unwanted side effects at six months. The group that had drug remedy and adopted the modified Atkins food plan confirmed an enchancment in all areas in comparison with the group that had drug remedy alone.
Tripathi famous that 33% of the contributors didn’t full the research as a result of poor tolerance of the food plan, lack of profit or the lack to follow-up partly as a result of COVID-19. Nonetheless, Tripathi mentioned tolerance of the modified Atkins food plan was higher than what’s seen with the ketogenic food plan.
“Whereas the modified Atkins food plan could also be an efficient remedy in controlling seizures, additional analysis is required to determine genetic biomarkers and different elements related to the response to this food plan,” Tripathi added. “This may increasingly enhance affected person care by encouraging focused precision primarily based earlier use of this food plan.”
A limitation of the research is that seizures have been self-reported or reported by caregivers, so some seizures could not have been reported.
The research was supported by the Division of Biotechnology, India.